This is my experience on Midodrine. I am not giving medical advice. My doctor prescribed it 2 times a day as needed. I was told not to take it before bedtime/or lying down it can be dangerous. You can look that information it is true. I was told if I feel like I need it (I know my body more than my physician does) then take it. I only use it during flare ups. It is silly for me to take a medication when I really am not symptomatic. I hope this helps