Does anyone know why it takes so long for someone with POTS to recover for driving or riding in a car for more than a couple of hours? I took a two hour trip recently, drank lots of water, rested. The next day, two hours back home, I had to go straight to bed and was there most of the weekend. I've asked Mayo Clinic if it's a blood flow issue, but nurse said no. My muscles ache, and I'm incredibly fatigued. I've been diagnosed for three years, and I take salt tablets, Cymbalta, Klonpin, Carpidoba, probiotics, and try to drink the recommended amounts of water and electrolyte fluids. I don't exercise regularly. Maybe that would help.