My doctor encouraged me to be on potassium, magnesium, and calcium supplements with Florinef, as it depletes your levels. I also have my potassium checked with a basic metabolic panel once a month. It would be worth it to ask you doctor about checking those levels to see if it is adding to your symptoms. When my potassium is low I have low energy, waves of fatigue/dropping sensations, heart rate issues, etc. I hope you're feeling better!