Report Midodrine - Dosage...? in Dysautonomia Discussion Posted April 30, 2015 I also take midordrine. I used to take 05mg 3 times a day now it is 10mg 3 xa day. but I have been told not to take it after 4pm. I passed out because I did not have any in my system when I was out one evening so now I take it when I need it no matter the time.