Muon

Are channelopathies associated with POTS or dysautonomia? What channels have been mentioned in literature, if any?

What types of adrenergic receptors are over or under expressed in POTS and in what tissue/cells? What are the findings in literature?

Thanks for sharing.

Neuroprotek shows the best effect out of all MC stabilizers I have tried. No other MC stabilizer had significant effect (anthistamines, montelukast, cromolyn). When I eat blood is being drawn away from other parts of the body (head for example) to the stomach and can lead to increased dysautonomia (blood pooling, breathing disruption, decreased digestion etc). Neuroprotek counters this and can just finish a meal in one-go. Food sensitivity improved. Increased resistance to stress in general. Diaphragma is easier to move during breathing. Didn't have flares of anxiety. Need less sleep. Slightly less pressure in lower part of spine. Been 3 weeks on 2x1 capsules and 10 days on 2x2 capsules so far in that order (will probably bump it up to 3x2 capsules in a couple of weeks). I started to notice a difference in symptoms ~1.5-2 weeks in. Side note: I'm having low blood pressure 61/96 (supine) and resting heart rate ~70 bpm (got this before taking neuroprotek). Never had low blood pressure in my life as far as I know. Got problems with vasomotor disturbances as well. These government lockdowns weren't good for my health either.

Option: You could Try Neuroprotek or PureLut, at least 2 capsules in the morning and 2 in the evening (build it up and could add 2 during mid-day if not strong enough) ) for a minimum of 4 weeks.

I didn't know that. Do you have a source of this?

Someone on the poiscenter forum had the same issue. He had elevated hBD2 in his stool and suspects it could be present in his urine as well. https://poiscenter.com/forums/index.php?topic=146.msg1344#msg1344 More: https://poiscenter.com/forums/index.php?topic=3739.msg39898#msg39898 Defensins in the Urinary Tract and Other Tissues

In what way? Sensitivities, digestion or lack of blood supply to the stomach? I have seen people complain about cloudy urine elsewhere. Do you have any problems with ejaculation?

Is postural orthostatic tachycardia syndrome (POTS) a central nervous system disorder? Same thread on Phoenix Rising forum Abstract Postural orthostatic tachycardia syndrome (POTS), a disorder of the autonomic nervous system characterized by a rise in heart rate of at least 30 bpm from supine to standing position, has been traditionally viewed as a dysfunction of the peripheral nervous system. However, recent studies and evidence from overlapping conditions suggest that in addition to being considered a disorder of the peripheral nervous system, POTS should be viewed also as a central nervous system (CNS) disorder given (1) significant CNS symptom burden in patients with POTS; (2) structural and functional differences found on neuroimaging in patients with POTS and other forms of orthostatic intolerance; (3) evidence of cerebral hypoperfusion and possible alteration in cerebrospinal fluid volume, and (4) positive response to medications targeting the CNS and non-pharmacologic CNS therapies. This review outlines existing evidence of POTS as a CNS disorder and proposes a hypothetical model combining key mechanisms in the pathophysiology of POTS. Redefining POTS as a CNS disorder can lead to new possibilities in pharmacotherapy and non-pharmacologic therapeutic interventions in patents affected by this disabling syndrome.

Inflammatory Biomarkers in Postural Orthostatic Tachycardia Syndrome with Elevated G-Protein-Coupled Receptor Autoantibodies

Low RR thread: https://www.dinet.org/forums/topic/31630-low-respiratory-rate-anyone/ Same here slow inefficient breathing.

https://www.dinet.org/forums/topic/31630-low-respiratory-rate-anyone/

"MCAS has been estimated to affect as many as 17% of the population with a severity ranging from mild to life-threatening." Ref On 11/9/2020 at 6:11 PM, KiminOrlando said: See Supplementary Table 4

Thanks. Nice tab btw. https://www.dinet.org/links https://www.dinet.org/links/postural-tachycardia-syndrome-a-practical-guide-to-management-and-associated-conditions-r270/

I placed it within a pinned thread on POIScenter. Ignore the POIS stuff, scroll down to other conditions, it's under the '1' next to POTS. It contains more useful links: POIS paper treatment summary