Yes, it does with my daughter. I think it is the main reason she isn't in school at all, now. In fact, I'm up now with her because she was feeling particulary bad (sh'e 15). Dr. Grubb says it can go with the territory of POTS. There are some sleeping meds you can try, but, they often don't work (at least they didn't with my daughter). Mayo says her sleep results are extreme, and she doesn't really get much significant sleep at all. I think there are a lot of PTS patients who suffer with this. Anyone have any thoughts? Joan