Hi, I have a lupus diagnosis and am presently on plaquenil. I was first diagnosed with lupus by a Rheumotologist in 1999. At that time I was not interested in taking any medication I just wanted a diagnosis that explained all the symtoms I had been afficted with for the past nine years. During my third pregnancy (1990) I developed flu -like symptoms and oral lesions. After the pregnancy I never quite got over those problems. Then in 1992 I ended up with aseptic meningitis ( thought to be viral, CSF protein 112 ) . After that I developed a malar rash and many other problems. I think that marked the beginning of my autonomic dysfunction. I have a very complicated medical history and to make a long story short I continued to accumulate more problems. In 2005 they all caught up with me and I lost the ability to work. I was referred back and forth to a number of different doctors and was diagnosed with CFS, Fibromyalgia and POTS ( I shoud have been diagnosed in 2001. If only a TTT had been done after a syncapal episode at work ). In 2008 I was referred to a different Rheumotologist for re-evaluation ( the earlier one had retired ). He diagnosed me with degenerative disk disease and Raynauds and re-diagnosed me with lupus and fibromyalgia.The lupus diagnosis was based on a positive ANA history, malar rash, photosensitivity, oral lesions, joint pain, history of pleuracy and other rashes. He strongly encouraged me to take Plaquenil. He said being on it would help protect my kidney. I only have one because one of them was removed along with a large tumor in 1995. So I decided to follow his advice and start taking Plaquenil. After about six weeks into it I noticed the horrible rash on my scalp had vanished, other rashes had lessened and there was improvement in joint pain. I was prescribed 300 mg daily. I have been seeing an Opthamologist every six months for eye exams but was advised last week that once a year is now acceptable. I have been told that lupus may be the cause of my autonomic neuropathy and POTS. I hope this information is useful and you get the help and answers you need. It can be a very long and frustrating journey I know but hang in there. Janet