Report I Was Just Given Mestinon -- Is That A Common Treatment? in Dysautonomia Discussion Posted May 10, 2013 LMG - My chronic low blood pressure has been raised which I've attributed that to the florinef but perhaps mestinon is playing a role there. As for heart rate, DIY tilt test shows I rarely reach an increase of 30 bpm upon standing anymore which I definitely attribute to the Mestinon. i didn't start to feel better until being on Mestinon for a few weeks despite being on florinef 4 months prior. I was told Mestinon works as a messenger between the brain and the nervous system so perhaps the reason for feeling better is b/c of what Ramakentesh said, it boosts the parasympathetic activity. But I'm not so sure its working on vasoconstriction for me and am thinking Midodrine might help for that.Anybody using Midodrine on a 'as needed basis'? Dosage?