We could start a whole new thread on children traumatized by POTS, doctors, medication reactions, tests, and ERs! But that would just be miserable, so let's not. : ) It's a tough choice whether or not to continue the search for answers, but we parents do our best for our babies and that's all we can do. I was compelled to continue through dozens of doctors and ERs through three states--and ended up with big bills, a traumatized sick kid, and not much else. Yes, on-going reflux can cause permanent damage to the esophagus as well as lead to esophageal cancer. In DS's case, nothing helped the reflux except the POTS flare quitting. There is nothing we can do about it.