Thanks so much for your reply and good wishes. It's all trial and error isn't it? I think I've managed to suss out what has been going on and I think it's coming off the Nortriptyline! That is the best for AN and IBS and sleeping etc. I came off it and went on the Duloxetine, which didn't work in the same way. Then over the course of the last year and subsequent flare-up is definitely linked to my sleep disorders getting worse and my gut spasm, sweating, dizziness, diarrhoea etc. I'm going to see the doctor this week and I'm going to go back on the Nortriptyline asap. I knew that something odd was going on and after surfing the internet I have come up with the culprit. I think the Nortriptyline had made my sleeping deeper and with less REM sleep issues. Coming off it and onto the Duloxetine, which I also reduced, made the SA really kick in. The day-time sleepiness and sickness/diarrhoea/sweating and generally feeling well below par where making my life a misery. I haven't been able to do much at all because of the problems. My gut muscles are so sore from the contractions that take place during REM sleep-cycles. I hadn't heard of the gut-brain and that the gut works with the brain in sleep. The gut has always been the epicentre of my symptoms and as it has 100 million neurons, more than the brain, you can understand the connection! Amazing really. Now I need to calm it all down and it may help everything. I wonder how many of us are needing certain drugs and should stick with others? I wish I hadn't switched! Wishing you well and everyone else with this weird condition