Report Methylpred in Dysautonomia Discussion Posted December 13, 2011 I have taken it a lot. One thing to be careful of is whether or not you take fludrocortisone. I read somewhere that other steroids coupled with flornief can tax out your body. I wanna say cushingoid state but not sure. Also beware that it can cause tachycardia. When I was first diagnosed last year with pots a neurologist thouht I might have ms and have me 3 iv bags full of that stuff-- it was horrible. On the plus side though methylpred cures a lot of weird things like psoriasis etc. Another thing I should probably mention is that it made me hallucinate and feel very wired-- I had to go to the er twice for this and get sedated. But if you need it, you need it. I also don't think the pill form is as bad because it is easier controlled.