I have not taken licorice for POTS symptoms but did use it a few years ago as part of my treatment for GERD symptoms while being treated for tick borne illness as I was on heavy doses of antibiotics. My Lyme doc used a combination of traditional and alternative therapies for treatment and taking licorice tabs was one of the ways we controlled my GERD. That was well before my POTS diagnosis but I was starting my POTS symptoms at the time and I have to say that I often felt an "all around" sense of wellness that my doc and I couldn't really explain when I would take my licorice tabs. Maybe I was helping my undiagnosed POTS! I would say that if you have GERD, it wouldn't hurt to see if you can get some relief for that from the licorice. I do remember there being a warning on the bottle regarding taking licorice for people with heart conditions so you may want to look that up before takng it.