My wife has unfortunately been a "medical mystery" for the last 6-months, and I have been trying my best to figure out what is going on with her. The story is a long one, but I want to provide all the information that I can: My wife's past history includes having mono when she was 19, and was later diagnosed with CFS which would flare up from time to time. She also had a thyroidectomy a few years ago and is on hormone replacement pills. She gave birth to our daughter last May and everything went extremely well. In the months after she had lost quite a bit of weight and began feeling tired all the time, as well has having trouble controlling her body temperature (sometimes she felt too hot and would wake up drenched in sweat, and other times she would be so cold that she'd go outside in 105-degree weather in a sweater just to warm up). We attributed all these things to postpartum (losing weight, hormonal imbalances, etc.). Around early September she started feeling worse and would feel dizzy, like she was going to pass out, especially after going up the stairs to our bedroom. One night she was brushing her teeth and said it felt like "all the blood rushed out of her head" and she thought she was going to faint. She immediately sat down on the bed and we went to sleep. The next morning she felt really hot to me, so I took her temperature for the first time and it was around 103-degrees. We then went to the doctor and he tested her for the flu, strep, etc. and all the results were negative. He decided to send her for an x-ray and noticed a "gray area" in her chest. He then sent her for a CT-scan and there was a mass present in her chest. After that she had a biopsy and we discovered that she had Hodgkin's Lymphoma, a type of cancer in the lymphatic system. This, of course, was terrifying as we had a 4-month-old baby and now we find out she has cancer. The good thing is that Hodgkin's is very treatable and has a high survival rate, so the outlook was good. We were set up with an oncologist who laid out a plan for chemotherapy, got a port-a-cath implanted, and got started on treatment. In the meantime, the fevers would not stop no matter what medication they tried, and were spiking over 104-degrees at times. So, she went in for her first dose of chemo, can home that afternoon and all was well until the next morning when basically all **** broke loose: The next morning she woke up with a high fever (104.4), and her hands were shaking and hard for her control. It was quite strange. We contacted the oncologist and she said she had "never heard of that" and that we needed to "go to the ER and be evaluated by a neurologist". So we went to the ER and they did an MRI of her brain and spine, both of which came back perfectly normal. They were worried about the fever, though, so they admitted her to the hospital to test her for infections, etc. This was on a Sunday night, and Monday she was worse. She was having trouble walking to the bathroom and back (her legs were shaking really badly) and eventually they put a catheter in so she could stay in bed. In the meantime they could not find an infection so they assumed the cancer was causing the fever (lymphoma is notorious for this). They gave her every type of drug they could think of: tylenol, indocin, high-doses of steroids, etc. and nothing touched the fever. By Tuesday night she was at a temp of 104.4 so they brought her down to intermediate care. By the time she was there, her temp was up to 105.6. The only thing they could think of was to put her on a cooling blanket to physically cool her like they would with a hyperthermia patient. The cooling blanket worked, but it was quite miserable for her as you can imagine. By this point she was on so many drugs that she was out of it anyway. The next morning things were no better and she went down to ICU where she spent a week. Physical Therapy would come in and try to stand her up, but she was so shaky and her heart rate would jump up to nearly 200bpm when they tried (her resting rate was in the 140s-150s). Magically, she got better soon after and went back to intermediate care, and then to a room. While she was alert and everything, she still had fever that they could not control without ice packs, etc. and still had high heart rate. She also began to have quickly-worsening neuropathy to the point where she could not walk anymore, and her feet became so painful that she was in tears just from the sheet touching them. After 5-weeks in the hospital, she went to a rehabilitation hospital where they were going to work on getting her to walk again. She was there for 4-weeks and made great improvement physically, though she still had the fever/heart rate issues the entire time. The doctors kept doing more tests: spinal tap, bone marrow biopsies, CT-scans, etc. and everything was negative. Also, the good news was that the cancer was responding extremely well to chemo and every scan they did showed great improvement. This was especially puzzling the doctors because if the cancer was going away so quickly, the symptoms (fever, etc.) should have completely disappeared by that point. She was discharged to go home in mid-December and it went well for the first few days. She was still not able to walk or go up the stairs, but she could get around with a walker/wheelchair. We had therapists coming by for home visits as well throughout the week to work on getting her stronger. Then, about a week after she got home, her mom called me and said that the therapist was very worried. My wife's temp was around 104 and her heart rate was almost 160. I called the oncologist who told us to go back to the hospital, and that she would arrange for us to go to MD Anderson (top cancer hospital in the country) to see if they could help. She said she was basically out of ideas and didn't know what else to do (I admire her for still trying her best to help, though). So, we spent 3-weeks at MD Anderson and saw some truly brilliant doctors who did even more testing. They were also baffled by the fevers and heart rate, saying that they have never seen Hodgkin's act like this, and they have pretty much seen it all. They even did her pathology over again to make sure she was correctly diagnosed in the first place (she was). They had their rheumatologists come in and test her for autoimmune diseases like Lupus, Still's Disease, etc. and found nothing. They also did and EEG/EKG of the heart and found no problems, just sinus tachycardia that seemed to be there for no reason. We spent Christmas and New Years there, which sucked, but at least they were able to rule out a lot more. A neurologist came by and did many tests and said that while many people undergoing chemotherapy end up with some neuropathy, he had never seen it this severe and especially not after the very first dose. His opinion was that she had some sort of "preexisting condition that was aggravated by the cancer and/or chemotherapy" (I think he's right). By this point she needed more physical therapy, so we went back to Austin and she spent another 4-weeks in the rehabilitation hospital. During this time she did well and her fever spikes stayed under 103 mostly. Her heart beat was also more in the 115-120 range. She ended up finishing chemotherapy there and was discharged in mid-February to come home. I was able to get a lot of time off from work, so I came home with her to help her get around the house, etc. Since then, we have hit many milestones: she made it up the stairs for the first time last week and got to sleep in her own bed for the first time in months, she was done with chemo and started radiation (which is easy compared to chemo), and we found out that she is in remission from the cancer! Yes, the cancer is gone, which was the most wonderful news ever! Also, her nerves seem to be regrowing and she doesn't have pain as often or as severe as before. Her fine motor skills also seem to be coming back finally and her handwriting, etc. is really improving. Now, the troubling thing for me is that she STILL spikes fevers daily (up to 102-degrees and even 103 once) and while her heart rate is better (95-105bpm), it is still above normal and still gets up to 120 on occasion. We told her radiation oncologist about it and he said that he has no idea what is causing the fever, but it is obviously not cancer related at all at this point. So, what do we do now? This is obviously something outside of the field of oncology and they have (understandably) thrown their hands up. The rheumatologists found nothing either, and she's seen many infectious disease specialists who said that she does not have an infection of any kind. All MRIs, etc. came back normal. And still, this started with weakness/dizziness, then to high fever, and then after the first dose of chemo severe nerve damage that is still not allowing her to walk, drive or be independent in any way. As for the fever, it is the one that scares me the most. I'm so afraid of it getting too high and me not being able to do anything to help her. As one doctor said, it is like her "thermostat is broken". Her whole face will flush bright red, and sometimes even her arms and chest will have red areas. The strange thing is that where her skin is red it is burning hot, but anything outside of the red area is cool to the touch. The doctors have no idea why that happens. Also, she does not sweat at all when the fever breaks... she just gets hot very quickly (1-2 degrees in literally 20-minutes sometimes), and then it will eventually drop, almost as quickly, but it never goes lower than 99-100 (her temp before all this was typically around 97-degrees). I'm sorry that this is such a long post, but I didn't want to leave anything out (though I probably did). Does ANY of this sound like dysautonomia at all? I have read that it is possible for dysautonomia to not really show up until something "sets it off", such as cancer and/or drugs like chemotherapy. I can say that all this was A LOT worse when she first was diagnosed with cancer, and it is much better now that she's in remission, but it's not gone. If you do think it could be something somewhere in the spectrum of dysautonomia, what kind of specialist should we see about it? Are there any doctors in Texas (preferably the Austin area) that we could visit? Thank you so much for your time and for any suggestions you may have.