Dino, I experienced the same thing, but fortunately Topamax is currently working well for me. I had POTS for several years and then all of the sudden started getting the strange symptoms like you described. I couldn't figure out what they were, but I knew that whatever it was it was something totally different that what I had experienced with POTS before and eventually my doctor told me that they were silent migraines and he was absolutely right. Basically, I had a constant migraine for over a year a straight 365 plus with out any relief at all and like you I could barely do anything, I tried all kinds of things, but finally got relief after starting topamax. I think mine was triggered by taking anti depressants. For whatever reason I haven't had much success and have actually felt a lot worse with the standard treatments. Right now I only take two medications, fludrocortisone for POTS and topamax for both migraines and complex partial seizures. I control the rest with the normal extra salt and fluid intact, wearing my compression stockings (when I must, we have a love hate relationship) and other things I have found that work for me. When you talked about having a hard time talking on the phone, using the computer, etc... I would experience the same thing. I still do at times, but to a much lesser an tolerable extent. It was so overwhelming. Eating was terrible also because it would cause severe pressure over my temples and I felt like they were going to explode, it was awful! I would also get severe facial pain and sometimes numbness. I am sitting here racking my brain trying to think of something that worked that I could tell you to try, but there really wasn't much for me either. When you tried Topamax what kind of dosage where you taking? Did you start off gradually or at a higher dose from the start? I started off at 25 mg and have gradually increased and it has worked out well so far. Well, I have to get going my husband is yelling at me to come watch the FSU vs Florida game. GO FSU, although he would disagree! I honestly hope you get to feeling better! Feel free to PM me with anything Take Care!