Report Florinef And Hypothyroid Disease in Dysautonomia Discussion Posted September 19, 2009 My wife has hypothyroid (Hashimoto's) and is on Florinef for her POTS as well. She has not had any real problems being on the medicine however we have noticed recently that her BP is actually a little bit high at times. This has never NEVER been the case for her before and she only recently began taking Florinef (the beginning of August). I don't know if the Florinef is the cause of her increased BP (that is what it is supposed to do after all), but now sometimes her BP is as high as nearly 140/90. Not sure if this helps any but I thought I'd tryHello all,I'm about to start Florinef, and I was reading through all the information, and it keeps saying "tell your doctor if you have hypothyroid disease." I do have hypothyroid disease, but my doctor already knew this when he prescribed Florinef. From what I read, it sounds like being hypothyroid can sometimes make a low dose of Florinef have a stronger effect.Do any of you who have POTS and hypothyroid know anything about this?