Sorry to read that you are having such problems with meds. I also have POTS and have had such problems with meds. Dr.s tried so many I litterally was so sick I ended up in the er twice. To make a long story short I found at the University of Louisville School of Medicine they do a pharmacogenetic testing. In simple terms how your body reacts to meds. After getting the test done I found out I had a liver enzyme problem and any drug that goes through that enzyme I can't take, which includes all beta blockers and ssri. If you want more info the web site is www.pgxlab.com. The doctor that helped though this gave me her personal phone number there at the university and I can call her any time to see if I can take any new med a dr prescribes. Hope this helps. Maggie