Hi everyone, I decided to make a post about what i have been feeling lately, to see if any others with POTS have had similar experiences. So basically, I have been feeling quite depressed lately. And the confusing part is that it isn't for any particular reason. I have had POTS close to 6 years and I feel that I have a pretty good handle on it now, and can deal with it quite well. I have been happy while suffering from POTS. For a bit of background info, I was on Zoloft for the past 3 years or so. I was NOT put on an anti-depressant because I was feeling depressed, but because of the research showing that SSRIs can help POTS in some patients. This year I decided I wanted to get off of the Zoloft, because I didn't really feel that it could be helping all that much. Of course I did this with my doctor's blessing and did it very slowly. Was on 100 mg and went down to 75 for 2 weeks, then 75/50 for 2 weeks, then 50/25 for 2 weeks, then 25 for a full month, then 25 every second day. It took me months to get off it, and i did experience lots of common withdrawal symptoms such as nausea, headaches, dizzyness, crying fits, anger, but alas i have been completely Zoloft free for close to 3 months now. However, during all this time, I have been feeling very depressed. I cry almost daily, and not because i am sad about any one thing in particular but because every little thing that goes wrong, a bad mark on an assignment, a small argument with a friend of family member, little things that used to easily be dealt with feel like they are the end of the world, and i just have this overwhelming sense of hopelessness. Even when nothing seems to be going wrong in my life, I get sad and upset for no reason and just start crying. I have NEVER experienced this before, and am wondering what is going on with me?! I feel like it is important to stress that i have NEVER been depressed before, my family doesn't really have a history of depression, and even when my POTS was at my worse, when i cried, i cried for a reason! I am wondering now if i could still be going through withdrawal from the Zoloft so long after I stopped it! I have, like I'm sure most of you have, heard horror stories about Zoloft and other anti-depressants withdrawal and have even heard of a few select cases where the withdrawal symptoms were experienced for months after but i'm pretty sure it is quite rare? So I guess my question to all of you would be, have you ever experienced anything like this? What have your experiences been with depression, anti-depressants, and withdrawal? Any advice would be very much appreciated! My thoughts and prayers are with all of you! -Shannon