Hi all, This is my first post, having only recently discovered dinet. I have the POTS variety of chronic orthostatic intolerance. In terms of measurable phenomena, my heart rate goes from about 70 beats/min lying down to 85 while sitting and around 115 when standing up. My blood pressure slowly climbs up while I'm standing. I'm not usually aware of this (only if I take my pulse) but, as would be familiar to many of you here, I am painfully aware of how weak, lightheaded, uncoordinated, brain fogged, nauseous and exhausted I am. I have been getting good results with judicious use of Midodrine. Within about 30 mins of taking a dose, my functional ability increases markedly and I'm able to do many things physically and mentally that would otherwise be beyond me. After a few hours the curtain comes down, presumably as the drug finishes metabolising or whatever, and the exhaustion, brain fog etc etc once again take over. I am quite sensitive to some of this drug's dose-related side effects so I need to be careful to under-dose to be safe. It has been a real miracle drug for me, allowing me to once again be somewhat in control of my own energy (On really bad days, however, my usual dose won't work). The confounding thing is that this drug doesn't seem to change my tachycardia at all, even though it wipes away many of my functional limitations for hours at a time. It does elevate my blood pressure, but my blood pressure before the drug was never low, always normal for my age (or slightly high). This leaves me wondering why the drug works for me at all. I'd love to hear from other people who take midodrine/proamatine for POTS, especially to hear about whether the drug makes you feel better and if that improvement bears any relation to what your heart rate and bp are doing. Thanks, Rob