Katybug Posted December 27, 2015 Report Share Posted December 27, 2015 For anyone diagnosed with CVID, do you experience joint and soft tissue pain and migraine that consistently improve with antibiotics then gradually worsen after the final dose?I am not officially dxed with CVID but the new immunologist feels like I may have a mild variant of it. He says he's had patients describe this pattern with antibiotics to him before. My IgM and IgG total and 2 subclasses are low but not low enough for the official dx. Quote Link to comment Share on other sites More sharing options...
ks42 Posted December 29, 2015 Report Share Posted December 29, 2015 This is really interesting to me. I have not been diagnosed with CVID, but I have the exact same response to antibiotics that you describe. Recently, I went on Keflex for a UTI, and a lot of my really annoying symptoms - like brain fog, headaches, and pain - improved immensely while I was on it. About two days after I stopped it, I had probably the worst migraine I've ever had with this illness so far, and it wound up lingering for around 3 days at least. And the muscle and joint pain slowly crept back, to the point where once again it's unbearable. Also, right after finishing antibiotics, I also tend to get a lot of symptoms coming back that I haven't had since the very beginning of my illness.. it's weird.This has happened before, so I know it's not just the Keflex itself. I haven't considered CVID, but maybe that's something to look into a little more. The current hypothesis is that I may have a chronic, underlying infection causing my POTS, and the antibiotics are controlling it while I'm taking them. When I stop, the bacteria starts multiplying again, and when it comes flooding back, causes a worsening of toxic symptoms (like headache and pain). Don't know if that's truly the case or not - there's a lot of guesswork going on right now!!! Quote Link to comment Share on other sites More sharing options...
Katybug Posted December 30, 2015 Author Report Share Posted December 30, 2015 I found this site gives a good overview :http://primaryimmune.org/about-primary-immunodeficiencies/specific-disease-types/common-variable-immune-deficiency/ Quote Link to comment Share on other sites More sharing options...
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