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IV saline vs IV albumin


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Does anyone have any thoughts or suggestions as to why someone with suspected hypovolemia does not respond to any volume expansion measures, up to and including IV saline, but does respond to IV albumin?

I have asked and asked my specialist about this, but he says he doesn’t know and has no conclusions to draw from it.

I have considered it and come to a tentative conclusion, but would love to know what you all think.

I am about to see a few doctors and will be asking them this “quiz question”.

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