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Feeling “wired” after eating


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Hi all! I have POTS, diagnosed back in 2017. Since my onset of symptoms, I’ve had issues while eating and after eating with dizziness, tachycardia, etc. However, recently I’ve started to have this really uncomfortable feeling after eating; the best way I can describe it is being extremely “wired”, antsy, hyper or restless; almost like the feeling I get with adrenaline rushes sometimes when I’m standing / walking, but it lingers instead of being a quick spike. It makes me feel like I want to crawl out of my skin. It’s such an uncomfortable feeling and obviously unsettling. I was also recently diagnosed with PCOS back in November, and was informed I’m at a higher risk for diabetes, etc. I’m worried I could be having some blood sugar issues or insulin resistance, but I’m not sure if I’m thinking too much into it, or if this could just be part of POTS. I have had a similar experience with this feeling before with certain medications, etc. But just wanted to see if anyone else experienced this. Any input will be appreciated! Thanks :)

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Hello @Pupmum25 - yes. I know this feeling. I have HPOTS and this used to happen tp me after eating. Normally after a meal the parasympathetic system kicks in and diverts the circulation to the gut, in order to digest. As a result we often feel tired lazy afterwards ( think Thanksgiving !!! ). If the sympathetic system kicks in instead ( as it can happen in HPOTS ) then we experience an adrenaline rush instead - hence the symptoms you describe. 

I have learned the best way to deal with this is to avoid large meals entirely. I eat 6-8 "snacks" a day and avoid foods that require a lot of energy to digest - such as pasta, white bread, cakes etc. This has completely stopped these episodes to happen after eating. 

7 hours ago, Pupmum25 said:

I have POTS, diagnosed back in 2017.

Have they diagnosed you with HPOTS? Did they test neurotransmitters? And what meds do you take? 

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@Pistol thanks so much for the reply! I underwent autonomic testing at Mayo Clinic back in November and those results indicated no HPOTS. However. I wasn’t as symptomatic the week I was at Mayo Clinic, unfortunately-as weird as that sounds to say. So I didn’t experience the typical adrenaline rush feelings that I do during flares when I was there going through testing. So as of now, I have a standard POTS diagnosis but I experience these wired / rush type of feelings off and on, I just wonder if the testing “missed” something since I wasn’t in a flare during my visit at Mayo. I’m glad to know I’m not alone in experiencing these feelings though! Currently not on meds- I manage symptoms with salt, lifestyle mods, etc. We’ve tried Midodrine which I reacted negatively to, and was told a beta blocker wasn’t ideal for me since my resting hr goes so low (50s). So still kind of in a limbo with treatment. 

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Hi @Pupmum25 - yes, they gave me midodrine in the beginning and it did not work for me. My autonomic specialist ( not the prescribing physician ) told me later that it does not work in HPOTS. --- I too had autonomic testing done at Vanderbilt and it was normal - and I was NOT symptomatic at the time. I was diagnosed one year later by another specialist who did norepinephrine testing and it was elevated. --- I am glad to hear that salt, water and lifestyle changes are somewhat helping you. I hope it continues! If the adrenaline rushes continue I would ask for a neurotransmitter test again. Best of luck!!!

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Hello @Pupmum25I have a similar thing.

"However, recently I’ve started to have this really uncomfortable feeling after eating; the best way I can describe it is being extremely “wired”, antsy, hyper or restless; almost like the feeling I get with adrenaline rushes sometimes when I’m standing / walking, but it lingers instead of being a quick spike. It makes me feel like I want to crawl out of my skin. It’s such an uncomfortable feeling and obviously unsettling."

I have no POTS or hyper POTS, but exocrine pancreas insufficiency of unknown kind. I get postprandial symptoms that make me very restless.... it is sometimes, like the nervous system in my digestive system would be "activated", which in turn activates my brain.

I do not really understand it, but it became better on a mast cell stabiliser. Maybe because this slowed my gut. 

I would love to understand what is going on there. It is interesting to read about parasympathicus and sympathicus (as @Pistol said), because I have both symptoms... this wiredness is related to more fatigue for me, not usually a tired feeling (like in normally tired), but I am more vulnerable, more wired and more fatigued after eating, if that makes sense. It sometimes feels like a mechanical thing on the vagus (whyever), so what @Crazy Tired said is interesting as well.

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