Jump to content

Statement on COVID-19 and CFS/OI

Recommended Posts

This article is great and will help ease many worries felt by a lot of Dys patients. Please forward our thanks to Dr Rowe for taking the time to address concerns unique to the dysautonomia population !

Link to comment
Share on other sites

  • 3 weeks later...

He says nothing about the ACE issue.

Am I the only person who has noticed that ACE (Angiotensin-converting enzyme) is implicated in both Covid and POTS? the coronavirus gains access to human cells by plugging its spike proteins into the ACE receptors. ACE receptors are particularly prevalent in the lungs. Well, POTS patients often have altered levels of ACE in their blood plasma. Do we also have higher or lower numbers of ACE receptors? I don't know, but it would seem like having more ACE receptors would make you more vulnerable to the virus and having less ACE receptors would make you less vulnerable to the virus.  I am surprised no one else has commented on this yet on Dinet.  


Link to comment
Share on other sites

While appears true the virus can bind to the ACE2 receptors and may enter cells this way, it's not immediately clear how to use this information to protect people from infection.

As research delves into this virus more over time, other possibilities arise. In the link below, a recent paper describes through a docking model how ORF8 and surface glycoprotein could bind to porphyrin and how orf1ab, ORF3a and ORF10 proteins of the virus bind to and disrupt heme on the beta chain of hemoglobin, causing less hemoglobin that can carry oxygen. This article makes the argument that because oxygen binding is then decreased, the patient cannot keep their O2 saturation up, which is a reason they die, despite being on ventilators with oxygen being pumped into their lungs.  

This article makes a case for chloroquine efficacy to reduce the disruption of heme from porphyrin molecule by the virus.


There's a link to the PDF download of the entire article on the page the above link links to. The translation of this article is not perfect, as you will see. However, this is an example of one of the many new theories being generated in a short period of time. 


Link to comment
Share on other sites

  • 5 months later...

Join the conversation

You can post now and register later. If you have an account, sign in now to post with your account.

Reply to this topic...

×   Pasted as rich text.   Paste as plain text instead

  Only 75 emoji are allowed.

×   Your link has been automatically embedded.   Display as a link instead

×   Your previous content has been restored.   Clear editor

×   You cannot paste images directly. Upload or insert images from URL.


  • Create New...