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Statement on COVID-19 and CFS/OI


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This article is great and will help ease many worries felt by a lot of Dys patients. Please forward our thanks to Dr Rowe for taking the time to address concerns unique to the dysautonomia population !

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  • 3 weeks later...

He says nothing about the ACE issue.

Am I the only person who has noticed that ACE (Angiotensin-converting enzyme) is implicated in both Covid and POTS? the coronavirus gains access to human cells by plugging its spike proteins into the ACE receptors. ACE receptors are particularly prevalent in the lungs. Well, POTS patients often have altered levels of ACE in their blood plasma. Do we also have higher or lower numbers of ACE receptors? I don't know, but it would seem like having more ACE receptors would make you more vulnerable to the virus and having less ACE receptors would make you less vulnerable to the virus.  I am surprised no one else has commented on this yet on Dinet.  

 

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While appears true the virus can bind to the ACE2 receptors and may enter cells this way, it's not immediately clear how to use this information to protect people from infection.

As research delves into this virus more over time, other possibilities arise. In the link below, a recent paper describes through a docking model how ORF8 and surface glycoprotein could bind to porphyrin and how orf1ab, ORF3a and ORF10 proteins of the virus bind to and disrupt heme on the beta chain of hemoglobin, causing less hemoglobin that can carry oxygen. This article makes the argument that because oxygen binding is then decreased, the patient cannot keep their O2 saturation up, which is a reason they die, despite being on ventilators with oxygen being pumped into their lungs.  

This article makes a case for chloroquine efficacy to reduce the disruption of heme from porphyrin molecule by the virus.

https://chemrxiv.org/articles/COVID-19_Disease_ORF8_and_Surface_Glycoprotein_Inhibit_Heme_Metabolism_by_Binding_to_Porphyrin/11938173/6

There's a link to the PDF download of the entire article on the page the above link links to. The translation of this article is not perfect, as you will see. However, this is an example of one of the many new theories being generated in a short period of time. 

 

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  • 5 months later...

"The key at this stage is to be very rigid and strict about complying with the recommendations for social distancing and isolation. Remind your friends and family (skeptical or not) that this is no joke."

It really is happening.

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