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Conrad_hemsley

Mestinon - at what dosage to start feel benefits

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Hi all,

Started building up Mestinon about 4 weeks ago. Am taking 40mg per day right now and tomorrow upping to 50mg. I'm increasing the dosage very slowly since I'm experiencing a lot of (uncommon) side effects. I've been thinking about quitting because I don't feel any better on it, probably only worse. However I want to be 100% sure it's not for me given the amount of people who experience great benefits from it.

Hence, my question is: at what dosage have you all started to feel benefits (and what benefits), so that I can estimate at what point I can be positive it won't do anything for me?

 

Thanks!

 

 

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I got gut side-effects and have stopped increasing. I am taking 30 mg twice a day with an unexpected benefit: end of migraines! Anyone guess why? Must have something to do with acetylcholine....

I have not noticed benefits to fatigue levels but I may not be taking enough. 

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90mg three times daily, or sometimes 60mg 4 times daily.

Took 6 weeks to work up to the 60mg dose. For me helps a lot of things a little bit. quicker bp adjustment when first rising to standing, not quite as extreem of hr spikes, less fatigue.

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I'm on 15mg and have been on that from the beginning since my body is really sensitive to meds since having POTS. I found that within the first day I could tell it was having an effect on me, kind of had a 'drug high' type feeling for the first week, but I also noticed I could walk around a bit further and my body would recover faster from it. 30mg is the most I've done and I can definitely tell when I'm on that dose, can walk further/ recover faster but it causes too much of a feeling of head pressure for me.

The one downside I've felt with the drug is that my body gets used to it really quickly (the medication does have a short halflife), so I don't feel the same positive effects I felt the first few weeks I was on it. It just makes things maybe 5-10% better for me overall.

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