Conrad_hemsley Posted February 10, 2020 Report Share Posted February 10, 2020 Hi all, Started building up Mestinon about 4 weeks ago. Am taking 40mg per day right now and tomorrow upping to 50mg. I'm increasing the dosage very slowly since I'm experiencing a lot of (uncommon) side effects. I've been thinking about quitting because I don't feel any better on it, probably only worse. However I want to be 100% sure it's not for me given the amount of people who experience great benefits from it. Hence, my question is: at what dosage have you all started to feel benefits (and what benefits), so that I can estimate at what point I can be positive it won't do anything for me? Thanks! Quote Link to comment Share on other sites More sharing options...
RecipeForDisaster Posted February 10, 2020 Report Share Posted February 10, 2020 I take 60mg 3 times daily and it does help, just not dramatically. I am considering trying higher doses, with a doctors' permission, because I haven’t had side effects. Quote Link to comment Share on other sites More sharing options...
Sushi Posted February 11, 2020 Report Share Posted February 11, 2020 I got gut side-effects and have stopped increasing. I am taking 30 mg twice a day with an unexpected benefit: end of migraines! Anyone guess why? Must have something to do with acetylcholine.... I have not noticed benefits to fatigue levels but I may not be taking enough. Quote Link to comment Share on other sites More sharing options...
Julyrose Posted February 11, 2020 Report Share Posted February 11, 2020 90mg three times daily, or sometimes 60mg 4 times daily. Took 6 weeks to work up to the 60mg dose. For me helps a lot of things a little bit. quicker bp adjustment when first rising to standing, not quite as extreem of hr spikes, less fatigue. Quote Link to comment Share on other sites More sharing options...
Conrad_hemsley Posted February 11, 2020 Author Report Share Posted February 11, 2020 Thanks for your replies! @Julyrose at what dose did you start noticing the benefits? Quote Link to comment Share on other sites More sharing options...
Ovaconfident Posted February 11, 2020 Report Share Posted February 11, 2020 Straight away. It will lift you out of bed. You'll know it's working. Quote Link to comment Share on other sites More sharing options...
Julyrose Posted February 13, 2020 Report Share Posted February 13, 2020 for me, I noticed benefits at 60mg. Just be close to a bathroom for 20 minutes after you eat! Though, that calmed down after 3 months or so too. Quote Link to comment Share on other sites More sharing options...
statesof Posted February 13, 2020 Report Share Posted February 13, 2020 I'm on 15mg and have been on that from the beginning since my body is really sensitive to meds since having POTS. I found that within the first day I could tell it was having an effect on me, kind of had a 'drug high' type feeling for the first week, but I also noticed I could walk around a bit further and my body would recover faster from it. 30mg is the most I've done and I can definitely tell when I'm on that dose, can walk further/ recover faster but it causes too much of a feeling of head pressure for me. The one downside I've felt with the drug is that my body gets used to it really quickly (the medication does have a short halflife), so I don't feel the same positive effects I felt the first few weeks I was on it. It just makes things maybe 5-10% better for me overall. Quote Link to comment Share on other sites More sharing options...
Recommended Posts
Join the conversation
You can post now and register later. If you have an account, sign in now to post with your account.