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Northera Aka Droxidopa - Your Daily Dosage? How Does It Work For You?


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I am using Northera (Droxidopa) 100 mg. tablets 3 tablets 3x a day for orthostatic hypotension. So far it does not work for me. If you are using it, what is your final dosage and how does it work for you?

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Hi ronnie2016, welcome to DINET! I'm not familiar with this med but it is on my "to try" list. Am very interested to find out more and learn about people's experiences!

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I've been on it for a few days now and the results are mixed. After initially dropping to 69/49, my blood pressure seems to be staying up a little more than usual. I am also a little less lightheaded when standing. The major drawback has been that my heart rate is above 100 much of the time which makes me feel ehausted. I'm hoping that if I stick with it a while longer, my body will adjust and the good parts will outweigh the bad. It took me four months to finally get a prescription so I am very committed to making this work.

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What mg. dose are you on forum members? How long? I am changing to Northera 300mg. tabs.from 100mg. in my new prescription. I have only been on it two weeks
I wonder how the mgs. in 300mg. capsules can be varied. I am best at 400mg - but pulse rate about 105. At 200mg dose my orthostatic numbers kick back in.
You can't cut them in half - so what is the solution?

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I was up to four 100mg capsules three times a day when I had to just stop taking it. My heart rate was over 100 bpm almost all the time no matter what I was doing and I was getting dizzy on standing. I wasn't doing much better at lower doses either. The clincher was when I started to have an irregular heart beat and strong palpitations with significant chest pain. I have been off it for a few days now and I am still trying to recover from the effects. I am disappointed because this was my last medication to try - I've been through all the others with no success. .

Sorry that I can't be of much help, Ronnie.

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  • 2 weeks later...

I waited on this drug to be FDA approved for 3 years and finally last year got my chance to try it. The first day it worked 3 --100 mg first thing in the morning. My pressure would drop in the mornings to 60/45 and rise by 5 O'clock in the evenings to 220/115 but once I started Northera it fixed both problems. I felt normal --- life is great--after about 3 months I notice I must be 120 years old . I could hardly get in and out of car. The muscle soreness was awful. In addition the fatigue as un bearable . At first. I did not relate it to the Northera due to coming on so slow. I stopped it and within a couple days the soreness and fatigue stopped. I tried it back a couple times and same results. So, I am back on Midrodrine. I told my doctor I was doing it like an IV drip. I let it melt in my mouth and lay what is left aside and an hour later do more of what was left. My doctor thought that was a great idea. I have PAF. I waited so long for this drug and for awhile I felt normal. I hope this helps some of you understanding my story.

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HI,

I also take Droxidopa (300mg + 300mg + 200mg). I have taken it in 2 years now and I feel so much better than before. I also feel tired often but it varies. I do not think it is because of Droxidopa. I always have had this terrible fatigue but it is better now than earlier. I usually get more chestpain when I am more tired and than I also feel more weak and so on. My body needs high doses of adrenaline/epinephrine because of autoantibodies which attack the epinephrine my body is producing. I have always been extremly active like persons with hyperactivity Syndrome and that helped me beeing able to live an ok life. When I stress my body it increases the epinephrinelevels and than I work better. When I told my physician that I do not tolerate inactivity at all and that high activity does that I feel better, he guessed that Droxidopa could be helpful. And than the bloodtest showed us that he was wright. Today I am not free of symptoms, but I am much better. Droxidopa is not working on everyone. It maybe is a good drug till just a few patients, but it is worth to be tested.
Another drug I am very thankfull for is nitroglycerine which helps for chestpain/coronary artery spasm. Life is so much easier with that even if you get pretty dizzy of taking it. But that is just temporarily in 20-30 min.

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