New Article - Autoimmune Pots

[Guest Alex]

Autoimmunoreactive IgGs against cardiac lipid raft-associated proteins in patients with postural orthostatic tachycardia syndrome. Xiao-Li Wang, Tian-You Ling, M Cristine Charlesworth, Juan J Figueroa, Phillip Low, Win-Kuang Shen, Hon-Chi Lee

Lipid rafts are specialized plasma membrane microdomains that serve as platforms for integrating cellular signal transductions. We have recently reported that autoantibodies against cardiac membrane proteins are present in patients with postural orthostatic tachycardia syndrome (POTS). In this study, we examined the presence of autoimmunoreactive IgGs against lipid raft proteins in these patients. IgGs were purified from the sera of 10 patients and 7 normal controls. Cardiac lipid raft preparations were isolated from normal human heart tissue. The lipid raft-associated proteins were resolved by 2-dimensional gel electrophoresis and immunoblotted against IgGs from each subject. Protein spots that reacted specifically with patient IgGs were identified by nanoLC-MS/MS. Thirty-four such protein spots, and 72 unique proteins were identified. The targets of autoimmunoreactive IgGs include proteins associated with caveolae structure, adrenergic signaling, calcium signaling, cytostructures, chaperone and energy metabolism. Multiple pathways were involved including those that regulate caveolae-mediated signaling, oxidative phosphorylation, fatty acid metabolism, protein ubiquitination, and cardiac β-adrenergic signaling. Our results suggest that cardiac lipid raft-associated proteins are targets of autoimmunoreactive IgGs from patients with POTS. Autoimmunity may play a role in the pathogenesis of POTS.

Copyright © 2013 Mosby, Inc. All rights reserved.

[ramakentesh]

Yeah interesting.

[Lel]

Agreed Ramakentesh. I wonder what percentage of POTSies also have autoimmune issues.

[Hope]

Thank you for posting. Another article for my binder. I don't have a medical background, so mostly what I understood was the last line! I have always thought mine was an autoimmune caused pots, and referring back to another article somebody posted here recently, I do believe if CFS is ever figured out so will my POTS be. It's great to see the research being done!

[Zap]

Excellent - Thank you!!

I'm taking this with me on Tuesday to my appointment as I've had a bad bout of symptoms lately. They're starting to find the missing links, and considering this is at Mayo, I wonder if/when they will offer actual testing. Maybe some of the markers could end up on the autonomic panel.