derekliz Posted February 14, 2013 Report Share Posted February 14, 2013 I am on Ivabradine and have been for almost a year (I live in the US). It definately has lowered my HR. Cannot wait to see the results of this study when it is released http://clinicaltrials.gov/ct2/show/NCT01761825?term=ivabradine&rank=8 Quote Link to comment Share on other sites More sharing options...
heathmcev Posted February 14, 2013 Report Share Posted February 14, 2013 Wow - me too! It doesn't look like they're still accepting participants. Hopefully that means the study will be out shortly. I cannot tolerate any BBs I've tried as they all lower my BP too much. In addition to lowering your HR, have you found that you have more energy? What positive effects has the med had for you?Thanks for posting about this.-dizzyde Quote Link to comment Share on other sites More sharing options...
Tobiano Posted February 15, 2013 Report Share Posted February 15, 2013 I'm also interested to hear the positive effects it has had on you. My cardiologist things that this would be the best med for me. Unfortunately it's not available where I'm from. Sounds like it's helping with your heart rate. Quote Link to comment Share on other sites More sharing options...
derekliz Posted February 15, 2013 Author Report Share Posted February 15, 2013 Initially my fatigue improved but the last few months it has increased again. Trying to determine if it is the Klonipin that is causing the fatigue. Some days are better than others. I take 5 mg of Ivabradine in the morning and my standing HR is anywhere from 65-75 and I take 2.5 mg at bedtime. I order it from a pharmacy in Canada. My specialist faxes over the script for me. Beta Blockers just wiped me out completely.liz Quote Link to comment Share on other sites More sharing options...
Tobiano Posted February 15, 2013 Report Share Posted February 15, 2013 Really - I'm in Canada!! I need to find this pharmacy!!! Quote Link to comment Share on other sites More sharing options...
Chaos Posted February 15, 2013 Report Share Posted February 15, 2013 I have been on it for about a month. It's been great for keeping my HR under control. I think I still prefer the propanalol for helping with controlling other symptoms in addition to the tachycardia, such as tremors, "tired but wired" feeling, palpitations and PVCs. My POTS doc wanted me to try switching to see if it would help with the fatigue and weakness issues but I'm not sure that I can tell a difference. I've had a major relapse of symptoms though from having a sinus infection/bronchitis so it's hard to say for sure.I'm in the US but was able to get it from the Canadian pharmacy that Derekliz used. They were very professional. Quote Link to comment Share on other sites More sharing options...
issie Posted February 15, 2013 Report Share Posted February 15, 2013 I was reading about this tonight. Has any of you seen that your left ventricular function has improved? What are the main effects that you can tell? It appears that it slows the heart rate down without affecting beta blockade like a beta blocker would do. It's supposed to up your exercise tolerance. Have you found this to be the case? Since it's not a beta blocker - I'm assuming it's an okay drug for those with MCAS?Issie Quote Link to comment Share on other sites More sharing options...
ramakentesh Posted February 16, 2013 Report Share Posted February 16, 2013 Some do really well on this medication in Australia where is commonly prescribed. its usually given to very tachycardiac patients and it reduces tachycardia/beta receptor stimulation without reducing overall sympathetic activity meaning it is less likely to worsen fatigue and dizziness. Quote Link to comment Share on other sites More sharing options...
DBP4620 Posted February 17, 2013 Report Share Posted February 17, 2013 does anyone know which doctor in Israel is doing the study? Is it Giris Jacob? I was thinking about trying to go overseas to get Ivabradine and do have family in Israel but since the trip is so difficult would want to make sure I see the right doctor and can get enough supply. Quote Link to comment Share on other sites More sharing options...
davecom Posted April 21, 2013 Report Share Posted April 21, 2013 Is there any news? I see the site has not been updated. It says February was the completion timeframe. I hope they didn't choose not to post results because they ******. Quote Link to comment Share on other sites More sharing options...
derekliz Posted April 21, 2013 Author Report Share Posted April 21, 2013 I have not followed up on the study.....completely forgot. Will have to put it on my radar and I hope that the results were positiveliz Quote Link to comment Share on other sites More sharing options...
Lethargic Smiles Posted July 8, 2013 Report Share Posted July 8, 2013 Derekliz, would some doctors have reservations about ordering a drug for patients from Canada? I really want to take this!! Quote Link to comment Share on other sites More sharing options...
derekliz Posted July 8, 2013 Author Report Share Posted July 8, 2013 Jackie, I am sure some doctors would have reservations about prescribing a medication that is not FDA approved. My doctor is the one who suggested that I try the medication as he researched it and had a patient already on it with good success. I would print out information about the medication and present it to your doctor....cant hurt to try!! Good LuckLiz Quote Link to comment Share on other sites More sharing options...
Tobiano Posted July 8, 2013 Report Share Posted July 8, 2013 I have since done more investigation. The drug is not currently approved in Canada. Quote Link to comment Share on other sites More sharing options...
derekliz Posted July 8, 2013 Author Report Share Posted July 8, 2013 Correct...it is not available from Canada but can be ordered from Canadian Phamacies. If you need the name of the pharmacy I order from, send me a privae messageLiz Quote Link to comment Share on other sites More sharing options...
davecom Posted July 8, 2013 Report Share Posted July 8, 2013 Interesting that the study results have still not been posted... Is that typical 5 months post completion? Quote Link to comment Share on other sites More sharing options...
Guest Alex Posted July 8, 2013 Report Share Posted July 8, 2013 Not sure what the typical time frame is Dave, but there are several older articles on the benefits of Ivabradine for POTS - mostly published in European journals by European specialists. If anyone's interested I could post links to those articles... there are 5 or 6 of them.Alex Quote Link to comment Share on other sites More sharing options...
Lethargic Smiles Posted July 9, 2013 Report Share Posted July 9, 2013 I'm interested! Especially in the peer-reviewed ones. Thanks in advance. Quote Link to comment Share on other sites More sharing options...
Guest Alex Posted July 9, 2013 Report Share Posted July 9, 2013 There you have them:http://europace.oxfordjournals.org/content/13/3/306.long Ivabradine in the treatment of orthostatic intolerancehttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC2995161/ Potentially New Indication of Ivabradine: Treatment of a Patient with Postural Orthostatic Tachycardia Syndromehttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC3043639/Single centre experience of ivabradine in postural orthostatic tachycardia syndromehttp://www.tkd.org.tr/english.asp?pg=:dergi/dergi_content&plng=eng&id=2039&dosya=190Successful use of ivabradine in a case of exaggerated autonomic dysfunctionhttp://europace.oxfordjournals.org/content/early/2007/10/19/europace.eum235.fullSymptom improvement in postural orthostatic tachycardia syndrome with the sinus node blocker ivabradineEnjoy,Alex Quote Link to comment Share on other sites More sharing options...
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