Warning - For The Geeky Scientist Types Of Us :) Renal Function And Possible Helps - But Interesting Scientific Info That May Apply To Pots????

[issie]

http://ajprenal.phys...5/F1020.full.pdf

Okay, the link on this didn't come up easily for some reason ---click on the third choice on what comes up - full pdf and then the first heading that comes up is Renocortical mRNA expression, is the article. Around about way to get to it ---but, it works. LOL

This is in relationship to the AD2A gene that I talked about in another thread.

It has some interesting info in regard to how this affects vasodilation and vasoconstriction in connection to the kidney. It is suggesting using spiralactone to help with renal dysfunctions ---and showing that it may be working on more than angiotension - but maybe the adenosine receptors. This system is connected to the renin/angiotension/aldosterone axis.

Not sure how it applies to us or if it does . . .have to re-read it and try to sort it all ---but, found it interesting.

Issie

[Guest maia]

Very curious geeky scientist type here.. very interested in this link and possible connections to cardiac amino acids with pots correlations...

Where's the link?! says url not found...

[issie]

You have to follow the directions I gave above to get to it. Around the world too. Third link down on what comes up ---says full pdf. Then the first heading is on Renocorticol mRNA - click on that title/article and it should come up for you.

Issie

[issie]

If you go down and start reading at the discussion level ---it won't lose you so bad.

This is showing that spironolactone was protective of the kidneys when there were issues with the renin/angiotension/aldosterone axis. It shows the connection of aldosterone and function with vasoconstricting and vasodilation and protection of the kidneys. Aldosterone also helps protect the function of the renal vascular tone. It causes vasoconstriction of the renal veins through a genomic mechanism. Spironolactone prevented the fall of the GFR. (This is a marker that determines chronic kidney disease and indicates the function of the kidneys and it's ability to filter. It is the marker used to determine the level of kidney dysfunction - that could lead to kidney failure.) Low salt diets increase renin production. Spironolactone prevents renal reuptake. Thus seems to improve renal function.

I thought this part was interesting: "Possible mechanisms by which aldosterone could regulate vascular tone include increased catecholamine vasoconstrictrictor effect, impaired vasodilation in response to acetylcholine, and upregulation of angiotension II receptors. Taking all these together, we reasoned that aldosterone might regulate vascular tone by altering the renal expression of vasoactive pathways, that is, by either increasing the expression of vasoconstrictor, reducing expression of vasodilator pathways, or both." "Sodium restriction by itself, however, is known to modify the expression of vasoactive pathways within the kidney."

The part that really seems to apply to us is in regard to adenosine pathway. (This is also what the CFS study seems to be focusing on in SLC. I posted about this on another thread) Sodium restriction seems to produce an upregulation of adenosine receptors but spironolactone prevented this - suggesting that the receptor is regulated by aldosterone. Renal vasoconstriction was associated with increase in Ad1 mRNA levels and reduction of the vasodilator receptor Ad2B.

Postaglandins are also important mediators of vascular tone, salt and water balance, and renin release.

This is a little bit of the summary of the article. It's really technical. But, it looks like spironolactone could be protective ot the renal system - if there is dysfunction.

I know a few have tried spironolactone. What were your results with it?

Issie

[futurehope]

I was on a low dose for a while because it supposedly helped with hair loss. It tends to lower blood pressure so my POTS doctor thought that it was counter-productive for me to be on it. I've since stopped. Not sure if my low dose did anything for POTS except make my blood pressure a bit lower, which I do not need.

[Guest maia]

Hi and thanks for the explanation of the article. That seems to go along with the article i posted about the cardiac enzymes also. they seem to rehave an effect on the pathways you describe as well as influencing them themselves. When i click on the link you posted though, i get this:

Not Found

The requested URL /ajprenal/289/5/F1020full.pdf was not found on this server.

Do you have another link to it you could post?

[issie]

When i click on the link you posted though, i get this:

Not Found

Do you have another link to it you could post?

Sorry, I don't.

[Guest mattgreen]

So I can do a search, what is the name of the study?

[issie]

Renocortical mRNA expression of vasoactive factors during spironolactone protective effect in chronic cyclosporine nephrotoxicity.

There it is. But, I think I summarized what may be applicable to us with POTS.

Issie

[NMPotsie]

Thank you, Issie, for posting this and translating it. I'm not a dumb girl but this one was like latin to me. Aye! Thanks for making it clear. I'm glad for the "geeky scientist types."

[issie]

Thank you, Issie, for posting this and translating it. I'm not a dumb girl but this one was like latin to me. Aye! Thanks for making it clear. I'm glad for the "geeky scientist types."

The older I get the more interested I am in the science of things. LOL It intrigues me. Glad I can help.

Issie