ramakentesh Posted July 3, 2012 Report Share Posted July 3, 2012 True Hyper POTS - as in central sympathetic drive or NET deficiency responds to melatonin as it improves cerebral autoregulation. Quote Link to comment Share on other sites More sharing options...
HyperPOTS8 Posted July 3, 2012 Report Share Posted July 3, 2012 Rama, not according to Dr Sandroni at Mayo. Quote Link to comment Share on other sites More sharing options...
ramakentesh Posted July 4, 2012 Report Share Posted July 4, 2012 What isnt according to Dr Sandori? Mayo published an article about a year ago suggesting hyperadrenergic presentations were compensatory. Quote Link to comment Share on other sites More sharing options...
RichGotsPots Posted July 4, 2012 Report Share Posted July 4, 2012 Rama you may be right about mention, but then the same can be said for chlonidine. But these two meds are only scratching the surface, I've found more potent adreniline inhibitors then these with less side effects. If my ne is hyperactive I'll be experimenting in that direction.. But I think that hyper or not it's not the issues the problem is that probably everyone of us has dysfunctional ans neurotransmitters,the problem is how to get that equilibrium back for everyone how to evaluate this dysfuction on a deeper level. Why aren't they figuring out ways to continuously monitor our neurotransmitters activity?Anyway I'm always for non pharm treatments, still believe that resQguard is one of the coolest, innovative techs for us and hardly anyone has beEn tried on it. I Found this interesting device that acts on central sympothetic drive hyperactivity. http://www.ardian.com/ous/medical-professionals/procedure.shtml it aim is actually on lowering BP... But I wonder how it might act to balance it too along with neurotransmitter activity.. Quote Link to comment Share on other sites More sharing options...
ramakentesh Posted July 4, 2012 Report Share Posted July 4, 2012 OOPS Sorry! My post meant to say that true Hyper POTS responds to Melatonin!!! My bad!!!!! Sorry!! Quote Link to comment Share on other sites More sharing options...
ramakentesh Posted July 4, 2012 Report Share Posted July 4, 2012 Rama you may be right about mention, but then the same can be said for chlonidine. But these two meds are only scratching the surface, I've found more potent adreniline inhibitors then these with less side effects. If my ne is hyperactive I'll be experimenting in that direction.. But I think that hyper or not it's not the issues the problem is that probably everyone of us has dysfunctional ans neurotransmitters,the problem is how to get that equilibrium back for everyone how to evaluate this dysfuction on a deeper level. Why aren't they figuring out ways to continuously monitor our neurotransmitters activity?Anyway I'm always for non pharm treatments, still believe that resQguard is one of the coolest, innovative techs for us and hardly anyone has beEn tried on it.I Found this interesting device that acts on central sympothetic drive hyperactivity. http://www.ardian.co...procedure.shtml it aim is actually on lowering BP... But I wonder how it might act to balance it too along with neurotransmitter activity..The problem with that logic is that despite NE being overactive in some areas, NET inhibition effects different areas differentially and you often see reduced central activity and impaired cerebral autoregulation, so reduced MAP in the brain basically, meaning reductions in sympathetic outflow might cause worsening dizziness as with beta blockers. Increased sympathetic drive as in essential hypertension does not cause POTS symptoms so in some ways they might be barking up the wrong tree in a way. Quote Link to comment Share on other sites More sharing options...
RichGotsPots Posted July 5, 2012 Report Share Posted July 5, 2012 So I finally got my results back my epi was 80 and my norepinwas 630. The doctor said that 800+ is hyperadrenic but this article says 600+ so do I have it or not I'm confused? Quote Link to comment Share on other sites More sharing options...
Anoj Posted July 5, 2012 Report Share Posted July 5, 2012 do exact numbers really matter? imo numbers are just a range. my NE wasn't up to 600, but when i did the TTT, it jumped dramatically (several hundred points), and my adrenals "kicked in with a vengeance," according to my doctor. so, i don't really go by what the numbers are, i just know that when i stand up my BP and NE rise dramatically and i have pre-syncope/dizziness. so i'm being treated accordingly, as hyper POTS.same with POTS. i didn't get the 30 pt. rise in BP ... can't remember whether it was 20 or 25 ... i asked my doctor point blank if i had POTS, and he said yes. i don't think i fit the clinical criteria, but i know i have some form of dysautonomia. i'm not really sure how much of an expert my doc is, anyway. Quote Link to comment Share on other sites More sharing options...
RichGotsPots Posted July 5, 2012 Report Share Posted July 5, 2012 Anoj- I think the number counts that's the point. I actually don't know my supine ne number though, maybe I will take a look at my 24 hour urine test to see, but had that in November.. Did you try treatment not directed at hyperadrenic 1st or did you wait until after that test and then start treatment? Sounds like you need a new doc... Quote Link to comment Share on other sites More sharing options...
Anoj Posted July 6, 2012 Report Share Posted July 6, 2012 Did you try treatment not directed at hyperadrenic 1st or did you wait until after that test and then start treatment? Sounds like you need a new doc...yep, i sure did. i went from midodrine + florinef to a BB. my doc does leave something to be desired. my BP raised so much, though, it was obvious there was some type of hyper response going on.these were my numbers. based on them, it doesn't look like i meet the criteria, if judging by NE alone. what about the others? catecholomine? why did the epinephrine jump?Baseline:Catecholomine, plasma 480 (ref range <504)Norepinephrine 442 (ref range <420) this was high-out of range on baselineEpinephrine 38 (ref range <84)Dopamine <30 (ref range <60)Upon HUT:Catecholomine, plasma 611Norepinephrine 479Epinephrine 132Dopamine >30i think i was confusing catecholomine earlier with NE. Quote Link to comment Share on other sites More sharing options...
RichGotsPots Posted July 8, 2012 Report Share Posted July 8, 2012 Anoj- Looks like your NE is normal on HUT but high supine, that may be interesting to pursue, if you pm me I can talk to you about it more.. I'm not sure what a spike in epi means or what level is high but my epi was only 80 something... None of those treatments are for hyperadrenic just general pots...Rama- sounds like you are hitting on one of my first pots theories when I first came on the board. I thought BP issues might be selective to different organs/areas in the body. Sounds like you are saying these NET issues are selective. But this do they even have a test that can test catecholamines in different areas selectively? I think there maybe actually... That's why i think everyone is getting affected in different ways by all of these pots meds because most are systemic and not selective.. Quote Link to comment Share on other sites More sharing options...
ramakentesh Posted July 8, 2012 Report Share Posted July 8, 2012 do exact numbers really matter? imo numbers are just a range. my NE wasn't up to 600, but when i did the TTT, it jumped dramatically (several hundred points), and my adrenals "kicked in with a vengeance," according to my doctor. so, i don't really go by what the numbers are, i just know that when i stand up my BP and NE rise dramatically and i have pre-syncope/dizziness. so i'm being treated accordingly, as hyper POTS.same with POTS. i didn't get the 30 pt. rise in BP ... can't remember whether it was 20 or 25 ... i asked my doctor point blank if i had POTS, and he said yes. i don't think i fit the clinical criteria, but i know i have some form of dysautonomia. i'm not really sure how much of an expert my doc is, anyway.Oh my god finally some logic Quote Link to comment Share on other sites More sharing options...
RichGotsPots Posted July 8, 2012 Report Share Posted July 8, 2012 here's an idea that will not go anywhere lol what if it's not just the level of catecholamines but the sensitivity we have to them being dysfunctional..its not going to go anywhere because no one is going to look under the surface... Quote Link to comment Share on other sites More sharing options...
ramakentesh Posted July 10, 2012 Report Share Posted July 10, 2012 (edited) Alpha and beta receptor hypersensitivity has been described and examined in MANY studies on POTS. Edited July 10, 2012 by corina Quote Link to comment Share on other sites More sharing options...
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