sue1234 Posted February 17, 2012 Report Share Posted February 17, 2012 Okay, I had a lot of labs done at my first appt. at Mayo. I saw an endocrinologist, but he also is sending me out to a neurologist and cardiologist for the POTS. I already completed the autonomic reflex testing portion and a chest x-ray. I have to do a mixed-meal test to see what happens with my glucose/insulin, but it won't be until my return appts. in April.I had alot of endocrine labs done, and I'm just going to mention the ones that were, well, weird:cortisol: --24-hour urine was on the low end(9) --serum was on the high-normal end(23)ACTH: --serum was on the high-normal end(52)So, with them both on the top-normal end, that's not right. They are supposed to be opposites(one low, one high, etc.). IF they would both be above range, that would be very indicative of pituitary Cushing's. I actually sent a brain pituitary MRI from 5 years ago to a neurosurgeon that reads MRIs for Cushing patients, and he actually said he saw a two areas that could indicate small possible tumor areas, and to see if my cortisol specifically ever gets abnormal with time. Well, it is getting here. So, I forwarded that email out and am forwarding it to my new endo. I've looked back at some posts here and there were actually 25% of poll responders on adrenal function who said they had high cortisol. So, what's going on here?aldosterone: --was on the low-normal end(5), and was a 3 a few years agorenin: --was on the low-normal end(1.2).I always wonder why these don't seem to be higher considering I seem dehydrated in my mind. But, then I read on a lab website that in the situation of Cushing's disease, you would have high cortisol, low aldosterone and low renin. So, maybe it's finally all piecing together. Of course, right when I think an answer might be coming, I get told everything is "normal".I had a protein electropheresis where all the alpha, beta and gamma globulins were 0.1 under the upper limit, and one was over--the alpha 2 globulin. I see it is related to transcortin, and also known as cortisol-binding globulin(CBG), which was not tested.So, CBG binds cortisol, aldosterone, and progesterone. I find that interesting, but still trying to see how that might all fit into POTS or not. Of course, I can see if it alters the available cortisol and/or aldosterone, that could explain feeling like cr*p!So, how does the endocrine system fit into all this?? It's actually possible I have a pituitary tumor, and I've read of at least three other people here mention that they have pituitary tumors. I've read about 5-6 others say they have elevated cortisol. I won't find out anything for a couple of months, and time already seems to be creeping until my next appt.!Oh yea, and I forgot to mention my already possible issue with my ADH always being low. That was not retested, so don't know if it's still low. But I did have to ask for a larger jug when they gave me mine to do the 24-hour urine in. They must not get many ask for it because they had to go to the back and get one. I was a tad conservative with my drinking and still managed 3100 mls.And lastly, the reason I went was the glucose and insulin issue. I won't have anything to report on that until I go back. But, it seems alot of my endocrine things are just "off". Quote Link to comment Share on other sites More sharing options...
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