julieph85 Posted February 9, 2012 Report Share Posted February 9, 2012 I'm curious because so many of us are women and some of us it started during pregnancy. There is a theory that autoimmune disorders are so prevalent in women because they can be triggered and mediated by hormones. Maybe something with estrogen and progesterone? Quote Link to comment Share on other sites More sharing options...
julieph85 Posted February 9, 2012 Author Report Share Posted February 9, 2012 http://jcem.endojournals.org/content/84/2/606.full Quote Link to comment Share on other sites More sharing options...
Lemons2lemonade Posted February 9, 2012 Report Share Posted February 9, 2012 Julie, have you googled pregnancy and angiotensin ii yet? Quote Link to comment Share on other sites More sharing options...
lissy Posted February 9, 2012 Report Share Posted February 9, 2012 Well I always thought hormones were the cause of my problems and all hormonal testing has been normal. Until recently nothing has been abnormal until they found a mass on one of my ovaries, which they have to remove the ovary and I suggest having a hysterectomy (Feb.28th) and my doctor agreed. I will be having a radical hyster leaving only 1 good ovary.So I guess I will know soon if my hormones were playing a part of my POTS.I know for sure stopping my cycle is going to be helpful and with only one ovary should be less hormonal activity. I believe I have had POTS since I was a teen but pregnancy made it progress in my case. I will keep an update on my recovery and hopeful improvements! Quote Link to comment Share on other sites More sharing options...
brethor9 Posted February 9, 2012 Report Share Posted February 9, 2012 I crashed completely after a partial hysterectomy....kept my ovaries....I have no doubt that hormones are somehow tied in to my illness somewhere...I just dont know how and none of my specialists are willing to connect the dots ....it seems so obvious to me ;(Bren Quote Link to comment Share on other sites More sharing options...
Lemons2lemonade Posted February 9, 2012 Report Share Posted February 9, 2012 Julie, I also have had my estradiol and testosterone tested. Testosterone was slightly high once, then back to normal. Quote Link to comment Share on other sites More sharing options...
julieph85 Posted February 9, 2012 Author Report Share Posted February 9, 2012 Bren your mention of your hysterectomy in a previous post is what made me think of it Quote Link to comment Share on other sites More sharing options...
julieph85 Posted February 9, 2012 Author Report Share Posted February 9, 2012 Lemons, yes I have. I also had preeclampsia at the same time my pots started at the end of my pregnancy. There is a theory that preeclampsia is related to ang 2 Quote Link to comment Share on other sites More sharing options...
julieph85 Posted February 9, 2012 Author Report Share Posted February 9, 2012 http://www.ncbi.nlm.nih.gov/m/pubmed/16275247/ Quote Link to comment Share on other sites More sharing options...
issie Posted February 9, 2012 Report Share Posted February 9, 2012 Lemons, yes I have. I also had preeclampsia at the same time my pots started at the end of my pregnancy. There is a theory that preeclampsia is related to ang 2Julie, The thought is autoantibodies to ACE2 - it's a little different. It comes before angiotension 2 Quote Link to comment Share on other sites More sharing options...
issie Posted February 9, 2012 Report Share Posted February 9, 2012 http://www.ncbi.nlm....ubmed/16275247/Wow, that study shows the complete opposite opinion than the one I read earlier. The study I read said that estrogen would increase angiotension 2 and cause high blood pressure and cardiac symptoms. I suppose if that's what you need to have done - it would be good. If you have low angiotension 2 levels and low blood pressures. But, for us with high bp's and possible high angiotensions - maybe not so good.I wrote on the earlier post when you brought this up. So, many have endometrosis involvement and have had hysterectomies due to that. The idea is that endo is from too high estrogen. It makes you wonder if there is a connection. We are bombarded in life with estrogen exposure all around us - in our foods, plastics etc. So this could also affect males. Quote Link to comment Share on other sites More sharing options...
jangle Posted February 9, 2012 Report Share Posted February 9, 2012 Estrogen most definitely is involved with POTS. It's realistically the only thing that explains why there are more female patients with POTS than male patients. I haven't researched into this enough I'd have to read up more on what's going on with estrogen/angiotensin ii and other relevant hormones that estrogen might influence. Quote Link to comment Share on other sites More sharing options...
ramakentesh Posted February 9, 2012 Report Share Posted February 9, 2012 In terms of autoimmunity? Quote Link to comment Share on other sites More sharing options...
issie Posted February 10, 2012 Report Share Posted February 10, 2012 In terms of autoimmunity?Not sure what you're asking, and to whom it's directed? Quote Link to comment Share on other sites More sharing options...
Lemons2lemonade Posted February 10, 2012 Report Share Posted February 10, 2012 Estrogen, angiotensin, both globulins. Quote Link to comment Share on other sites More sharing options...
ramakentesh Posted February 10, 2012 Report Share Posted February 10, 2012 Most mediators and neurotransmitters are effected by hormonal fluctuations so its hard to say Quote Link to comment Share on other sites More sharing options...
Trach Posted February 10, 2012 Report Share Posted February 10, 2012 What would it mean if your body could not tolerate any type of hormone therapy? Quote Link to comment Share on other sites More sharing options...
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