Lemons2lemonade Posted January 14, 2012 Report Share Posted January 14, 2012 Found this on vanderbilt's website,though I am sure many of you have read it,it seemed like a succinct break down of pots types and current research. http://www.mc.vanderbilt.edu/root/vumc.php?site=adc&doc=4788 Quote Link to comment Share on other sites More sharing options...
ramakentesh Posted January 14, 2012 Report Share Posted January 14, 2012 Yeah its not bad.More recently there has been a move towards theories of deconditioning (Dr.Levine), and impaired nitric oxide activation - both increased and decreased in POTS (Stewart/medow and the CHinese group). Vandy have not updated this information to include the two newer theories regarding hypovolumia - that it relates to angiotensin II and that it may relate to abnormal peripheral dopamine activity.Also I heard somewhere that NET deficiency is making a come back as a theory.The Clinical Trials website is a good place to look for current research directions from the various American groups at least. Quote Link to comment Share on other sites More sharing options...
Lemons2lemonade Posted January 14, 2012 Author Report Share Posted January 14, 2012 Rama, where do you find this info? Quote Link to comment Share on other sites More sharing options...
ramakentesh Posted January 14, 2012 Report Share Posted January 14, 2012 ive got a few sources and I do a bit of my own research:Mayo - who believe most POTS is autoimmune:http://www.mayoclini...t/82/3/308.fullBlair Grubb group on Hyper POTS:http://www.cardiolog...1_X_Kanjwal.pdfVandy find that QSART is abnormal in the same ratio of 'hyper' and non hyper POTS patients:http://www.ncbi.nlm....les/PMC3089763/Stewart and Medow break up POTS based on peripheral blood flow and catagorise Low Flow POTS:http://ajpheart.phys...87/3/H1319.fullhttp://www.clinsci.o...5/cs1100255.htmhttp://www.nymc.edu/...flow%20POTS.htmVandy confirm the finding of elevated angiotensin II in some POTS patients and suggest that it may impaire NET function:http://www.heartrhyt...1204-X/abstractStewart and Medows find that ascorbate (vitamin C) improves flow in Low Flow POTS patients:http://www.ncbi.nlm....pubmed/21622825Stewart/medows et al find that the largest subset of POTS patients have elevated neuronal or endothelial nitric oxide:http://www.ncbi.nlm....pubmed/21642500There is plenty more - on cerebral autoregulation, hydrogen sulfide and nitric oxide from China. Net Deficiency, impaired MIBG reuptake and a few other things. Quote Link to comment Share on other sites More sharing options...
potsgirl Posted January 14, 2012 Report Share Posted January 14, 2012 Thanks for all of the site information, lemons and Rama. I was a little disappointed that the Mayo link listed under Rama's post was not working, since I go there. Quote Link to comment Share on other sites More sharing options...
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