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It might be a possibility in some patients with OI. A lot of members here have had echocardiograms which didn't reveal a reduced stroke volume, so I don't think this theory can apply to all OI patients.

Also one has to question the issue of causality. For instance a lot of people who have OI might be prone to not exercising, and if they don't exercise for a long time that might result in a diminished LV heart size through deconditioning.

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