Noreen Posted August 18, 2010 Report Share Posted August 18, 2010 http://clinicaltrials.gov/ct2/show/NCT0097...c%22&rank=7Amazing that a recruitment size of 20 is sufficient if correct terminology is used. Quote Link to comment Share on other sites More sharing options...
ramakentesh Posted August 20, 2010 Report Share Posted August 20, 2010 its been around a while in testing for conditions of low orthostatic blood pressure but from what ive heard its believed not to be helpful in POTS. Quote Link to comment Share on other sites More sharing options...
Noreen Posted August 20, 2010 Author Report Share Posted August 20, 2010 Rama-Yes, you're right as usual. I didn't know full history of drug at time of posting.New press release from Chelsea therapeutics -"CHARLOTTE, N.C., Aug. 19, 2010 (GLOBE NEWSWIRE) -- Chelsea Therapeutics International, Ltd. (Nasdaq:CHTP) announced that a new investigator-led phase II clinical study of Droxidopa, an oral synthetic precursor of norepinephrine, has been initiated in chronic fatigue syndrome (CFS)......About DroxidopaDroxidopa, the lead investigational agent in Chelsea Therapeutics' broad pipeline, is currently in Phase III clinical trials for the treatment of symptomatic neurogenic orthostatic hypotension (NOH) in patients with primary autonomic failure ? a group of diseases that includes Parkinson's disease, multiple systems atrophy (MSA) and pure autonomic failure (PAF). Droxidopa is a synthetic catecholamine that is directly converted to norepinephrine (NE) via decarboxylation, resulting in increased levels of NE in the nervous system, both centrally and peripherally. Droxidopa is also being studied for the treatment of fibromyalgia and adult attention deficit disorder in two ongoing phase II trials and completed a phase II in intradialytic hypotension (IDH) study with positive results."http://www.stockmarketsreview.com/news/32812/The drug is a goldmine for the company and they did not have to pay for mining since they got orphan drug status through FDA.If the drug is even going to be tried it would have to be an off-label use if they are only given approval for MSA, PAF, and Parkinson's. Is the drug in use in Australia?noreen Quote Link to comment Share on other sites More sharing options...
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