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Droxidopa


Noreen

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Rama-

Yes, you're right as usual. I didn't know full history of drug at time of posting.

New press release from Chelsea therapeutics -

"CHARLOTTE, N.C., Aug. 19, 2010 (GLOBE NEWSWIRE) -- Chelsea Therapeutics International, Ltd. (Nasdaq:CHTP) announced that a new investigator-led phase II clinical study of Droxidopa, an oral synthetic precursor of norepinephrine, has been initiated in chronic fatigue syndrome (CFS).

.....

About Droxidopa

Droxidopa, the lead investigational agent in Chelsea Therapeutics' broad pipeline, is currently in Phase III clinical trials for the treatment of symptomatic neurogenic orthostatic hypotension (NOH) in patients with primary autonomic failure ? a group of diseases that includes Parkinson's disease, multiple systems atrophy (MSA) and pure autonomic failure (PAF). Droxidopa is a synthetic catecholamine that is directly converted to norepinephrine (NE) via decarboxylation, resulting in increased levels of NE in the nervous system, both centrally and peripherally. Droxidopa is also being studied for the treatment of fibromyalgia and adult attention deficit disorder in two ongoing phase II trials and completed a phase II in intradialytic hypotension (IDH) study with positive results."

http://www.stockmarketsreview.com/news/32812/

The drug is a goldmine for the company and they did not have to pay for mining since they got orphan drug status through FDA.

If the drug is even going to be tried it would have to be an off-label use if they are only given approval for MSA, PAF, and Parkinson's.

Is the drug in use in Australia?

noreen

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