ramakentesh Posted November 26, 2009 Report Share Posted November 26, 2009 (edited) Im just wondering whether this medication has any effect on two specific symptoms:1. Sensitivity to medications / etc2. jitteriness.thanks for any advice. Edited December 13, 2009 by flop Spelling of Mestinon corrected Quote Link to comment Share on other sites More sharing options...
janiedelite Posted November 26, 2009 Report Share Posted November 26, 2009 I'm on the 180mg timespan and it helps my fatigue, lowers heartrate and lowers my standing BP (normally I get hypertensive on standing).1. Not that I notice2. Not at all Quote Link to comment Share on other sites More sharing options...
ramakentesh Posted November 26, 2009 Author Report Share Posted November 26, 2009 So in your opinion its a winner? 60% symptom improvement? Quote Link to comment Share on other sites More sharing options...
bjt22 Posted November 27, 2009 Report Share Posted November 27, 2009 What do you mean by "jitteriness"? It does help with the constant tremors and lack of muscle strength for me. For example, I can now hold a baby and not fear dropping him/her. I don't think it has an effect on my blood pressure. I still get the ups and downs and still drop upon being upright. However, the drops don't feel as bad. Another benefit is the effect on my digestive tract. Does seem to help things move along a bit. Quote Link to comment Share on other sites More sharing options...
janiedelite Posted November 28, 2009 Report Share Posted November 28, 2009 So in your opinion its a winner? 60% symptom improvement?It's a keeper. I notice a 30% reduction in my overall fatigue. It lowers my standing BP too as well as my standing heartrate. It also provides some relief for my burning skin pain, surprisingly enough. Quote Link to comment Share on other sites More sharing options...
kayjay Posted November 28, 2009 Report Share Posted November 28, 2009 Thankful- did mayo clinic put you on this? They talked about it for me but sometimes it can raise blood pressure right?What about headaches? Quote Link to comment Share on other sites More sharing options...
janiedelite Posted November 28, 2009 Report Share Posted November 28, 2009 Yes, Mayo put me on it. I'm on the maximum dose. It caused headaches and a bit of jitteriness at first, along with nausea (which was the worst side effect for me so I was very careful to take the pill on a full stomach). After a week, I hardly had any side effects at all. Now I have the usual effects of the med, like excessive salivation, runny nose, and watery eyes. My BP has actually dropped since being on this med (especially my standing BP which is on the higher end). Mayo was careful to advise a maximum dose of 180mg/day, only to be taken during the day. The med is pretty much out of my system by bedtime for me. Quote Link to comment Share on other sites More sharing options...
erik Posted December 12, 2009 Report Share Posted December 12, 2009 I've not taken it but in regards to topic 1, I've seen brief mention of various medications "uncovering" an existing or borderline MG or "inducing" it. This could be perceived as "mestinon preventing sensitivity to a med" since it treats MG and might counter that other med's effect in that regard.Also, short of MG, generically speaking mestinon might potentially address most any "anticholinergic" side effect? And those are an aspect of so so many drugs. In this sense, if the "sensitivity" to the drug was related to an anticholinergic side effect, it could also satisfy the premise of topic 1. Quote Link to comment Share on other sites More sharing options...
ramakentesh Posted December 12, 2009 Author Report Share Posted December 12, 2009 POTS has many presentations that are similar to anticholerinegic states - for me anyway - visual accommodation problems, blurred vision, visual snow, tachycardia etc:Possible effects of anticholinergics include:Ataxia; loss of coordination Decreased mucus production in the nose and throat; consequent dry, sore throat Xerostomia or dry-mouth with possible acceleration of caries Cessation of perspiration; consequent decreased epidermal thermal dissipation leading to warm, blotchy, or red skin Increased body temperature Pupil dilation (mydriasis); consequent sensitivity to bright light (photophobia) Loss of accommodation (loss of focusing ability, blurred vision ? cycloplegia) Double-vision (diplopia) Increased heart rate (tachycardia) Tendency to be easily startled Urinary retention Diminished bowel movement, sometimes ileus - (decreases motility via the vagus nerve) Increased intraocular pressure; dangerous for people with narrow-angle glaucoma Shaking Possible effects in the central nervous system resemble those associated with delirium, and may include:Confusion Disorientation Agitation Euphoria or dysphoria Respiratory depression Memory problems[1] Inability to concentrate Wandering thoughts; inability to sustain a train of thought Incoherent speech Wakeful myoclonic jerking Unusual sensitivity to sudden sounds Illogical thinking Photophobia Visual disturbances Periodic flashes of light Periodic changes in visual field Visual snow Restricted or "tunnel vision" Visual, auditory, or other sensory hallucinations[1] Warping or waving of surfaces and edges Textured surfaces "Dancing" lines; "spiders", insects; form constants Lifelike objects indistinguishable from reality Hallucinated presence of people not actually there Rarely: seizures, coma, and death Acute anticholinergic syndrome is completely reversible and subsides once all of the toxin has been excreted. Previously, reversible cholinergic agents such as physostigmine was used but this was found to increase the risk of cardiac toxicity. The current recommended treatment is symptomatic and supportive management.That being said I dont have urinary retention - i got every twenty minutes or something ridiculous...but a lot of these symptoms are described in POTS by patients to some degree. Quote Link to comment Share on other sites More sharing options...
janiedelite Posted December 12, 2009 Report Share Posted December 12, 2009 Just as a follow-up, I'm not longer taking mestinon. We're not sure if it caused my recent episodes of coronary artery constriction (manifested by chest pains and elevated troponin). Quote Link to comment Share on other sites More sharing options...
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