firewatcher Posted May 2, 2009 Report Share Posted May 2, 2009 Normally a narrow PP is seen with hypovolemia (low total blood volume) which has been demonstrated in many cases of POTS. The theory behind this is a glitch in the Renin-Aldosterone system (The Renin-Aldosterone Paradox--Dr. Satish Raj.) I have come across an alternate, yet corresponding theory/reason and am wanting input from anyone who understands this better. There is a condition called isolated diastolic hypertension that creates a narrow pulse pressure through normovolemic vasoconstriction:Association of ACE genotype and predominantly diastolic hypertension: a preliminary study Pablo Martin Jim?nez,*Cecilia Conde,*Ana Casanegra,? Cesar Romero,*Aldo Hugo Tabares, Marcelo Or?as # http://jra.sagepub.com/cgi/content/abstract/8/1/42It involves Angiotensin II and NO. Increased Angiotensin II causes systemic inflammation and thus diastolic hypertension which narrows PP. The thing is, it is testable and far less invasive than a blood volume test.It sort-of crosses that barrier between Dr. Stewart's work and Vanderbilt's. Any theories? C'mon Ramakentesh--you've got to have a theory. Quote Link to comment Share on other sites More sharing options...
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