summer Posted April 26, 2009 Report Share Posted April 26, 2009 Since starting a combination of BB and Florinef almost a year ago, I have had improvement in a number of ways, although I still have a long way to go. I am able to stay standing for longer periods, I do not get as nauseated, I am not as tachycardic and my episodes are less often. I would say the combination has helped a lot.However, my brain fog has not changed. This is my most disabling symptom and is the thing that is holding me back in getting on with my life. I work as a nurse and can not do my job with out being fully alert all the time. It's very frustrating.I read a study from 1998, from Vanderbilt, called "Raised Cerebral Vascular Resistance in Idiopathic Orthostatic Intolerance: Evidence for Sympathetic Vasoconstriction" It suggests that symptoms of hypoperfusion are caused by constriction of the cerebral vasculature. This includes "altered mentation". I have read in recent posts about constriction of the carotids, but this and other research would seem to suggest it is more than that - that infact, there is perhaps a sympathetic response in the entire vaculature of the brain. When tested by my ANS specialist, he did a transcranial doppler which measured cerebral blood flow velocity. Mine decreased by close to 30% with upright position. According to the study I mentioned, normal controls dropped only 10%. Here is my question. BB are known to cause vasoconstriction and according to my doc have worsened Raynaud's syndrome for me. Does anyone know if BB can have vasoconstrictive effects on the brain as well? Could BB make brain fog worse?I know this is an old study and maybe some of you have more up to date info on cerebral vasoconstriction in POTS. I would love to know about it if you do. Thanks,Summer Quote Link to comment Share on other sites More sharing options...
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