Background: I have what is considered mild POTS, however my symptoms affect me greatly.. 40bpm raised supine heart rate (56-96). Small drop in BP. No syncope. Fatigue and brain fog are my worst symptoms and they are taking a toll on my life. My non-medical treatment includes increased fluids, sodium, exercise, compression garments sometimes (not wearing them much now because its really hot, didn't notice much difference with them anyway). Out of all those, exercise has been the most helpful, though it is often difficult because my body aches and I am tired.
I was prescribed Midodrine 5mg a couple months ago and I started taking it 4x a day every 4 hours. I started feeling a lot better immediately, huge improvement. More than any non medical treatment, besides exercise. Blood pressure and HR were normal. After a few weeks, I noticed that it wasn't helping as much, so I emailed my Dr. and they raised my prescription. I started taking 7.5mg every 3:30 hours, 4x a day. I felt a little better but not as good as a felt when I started taking the 5mg. I've been on the 7.5mg for a few weeks now, and I feel that its losing effectiveness. I am back to feeling very fatigued and brain fogged again.
I am really disappointed, I thought this was going to be a life changer but now I have to look for another drug.
Have others had this kind of experience with Midodrine?