Press Releases
Voglibose Inhibits Postprandial Hypotension
by David Douglas
NEW YORK (Reuters Health) May 24 - The alpha-glucosidase inhibitor voglibose can help reduce postprandial hypotension, Japanese researchers report in the May 9th issue of Neurology.
Lead investigator Dr. Takahiro Maruta of Kanazawa University and colleagues note that reduced blood pressure after a meal is common in the elderly and in those with conditions such as Parkinson's disease and diabetes mellitus. It can increase the risk of falls and coronary events.
To examine the effect of voglibose on postprandial hypotension, the researchers studied 48 elderly subjects including those with Parkinson's disease, multiple system atrophy and diabetes as well as elderly and younger controls with no autonomic disorder.
Within 2 hours of 75-g glucose loading, blood pressure fell by more than 20 mm Hg in 72.7% of the Parkinson's patients, all of those with multiple system atrophy, 27.3% of the patients with diabetes, 23% of the elderly controls and none of the younger controls.
Following voglibose administration, there was a significant reduction in this drop in blood pressure. Without voglibose the mean drop was 41.5 mm Hg; with voglibose, it was 21.0 mm Hg. There was also a reduction in the duration of postprandial hypotension under the two conditions (52.3 minutes versus 17.3 minutes).
Summing up Dr. Maruta told Reuters Health, "Many people suffer from symptoms due to hypotension. Our research should cast some light on ways to help them."
Neurology 2006;66:1432-1434.
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